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Tuesday, July 28, 2020 | History

2 edition of Bioassay of cinnamyl anthranilate for possible carcinogenicity found in the catalog.

Bioassay of cinnamyl anthranilate for possible carcinogenicity

National Cancer Institute (U.S.).

Bioassay of cinnamyl anthranilate for possible carcinogenicity

by National Cancer Institute (U.S.).

  • 140 Want to read
  • 40 Currently reading

Published by Dept. of Health and Human Services, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogenicity testing.,
  • Food additives -- Toxicology.

  • Edition Notes

    StatementCarcinogenesis Testing Program, National Cancer Institute, National Institutes of Health, and National Toxicology Program.
    SeriesCarcinogenesis technical report series ; no. 196, DHHS publication ; no. (NIH) 80-1752, NTP ; 80-10, DHHS publication -- no. (NIH) 80-1752., NTP (Series) -- 80-10.
    ContributionsNational Institutes of Health (U.S.).
    The Physical Object
    Paginationx, 92 p. :
    Number of Pages92
    ID Numbers
    Open LibraryOL15241368M

      Carcinogenesis bioassay of trichloroethylene: CAS No. by United States. National Cancer Institute. Carcinogen Bioassay and Program Resources Branch; U.S. Dept. of Health, Education, and Welfare, Public Health Service. National Institutes of HealthPages:   NCI (National Cancer Institute) Bioassay of Cinnamyl Anthranilate for possible Carcinogenicity Cas No. Technical Report Series No. Google ScholarCited by:

      GRAS Flavoring Substances 19 The 19th publication by the Flavor and Extract Manufacturers’ Association’s Expert Panel on recent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment. Bioassay of cinnamyl anthranilate for possible carcinogenicity [] National Cancer Institute (U.S.). Bethesda, Md.: Dept. of Health and Human Services, Public Health Service, National Institutes of .

    95 Schoental, R, and Gibbard, S Br J Can () 96 NCI "Bioassay of Cinnamyl Anthranilate for Possible Care mogenicity," NCI Tech Rep No , U S National Cancer Institute, Bethesda, Maryland, In enzymology, an anthranilate phosphoribosyltransferase (EC ) is an enzyme that catalyzes the chemical reaction. anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate ⇌ N-(5-phospho-D-ribosyl)-anthranilate + diphosphate. Thus, the two substrates of this enzyme are anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate, whereas its two products are N-(5-phospho-D-ribosyl BRENDA: BRENDA entry.


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Bioassay of cinnamyl anthranilate for possible carcinogenicity by National Cancer Institute (U.S.). Download PDF EPUB FB2

Mice Administered Cinnamyl Anthranilate in the Diet 51 Table Bl Summar of the Incidenc ye of Neoplasms in Male Mice Administered Cinnamyl Anthranilate in the Diet; Table B2; Summar of the Incidenc ye of Neoplasms in Female Mice Administered Cinnamyl Anthranilate in the Diet Appendix C Summar of the Incidenc ye of Nonneoplastic Lesions.

A bioassay of cinnamyl anthranilate (a synthetic flavoring agent) for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were fed the test chemical in diets contain or 30, ppm for weeks and then observed for an additional 2 or 3 weeks.

Get this from a library. Bioassay of cinnamyl anthranilate for possible carcinogenicity. [Mason Research Institute.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.)]. A bioassay of cinnamyl anthranilate for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were fed the test chemical in diets contain or 30, ppm for wk and then observed for an additional wk. Controls consisted of 50 untreated rats and 50 untreated mice of each sex.

Bioassay of anthranilic acid for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. OCLC Number: Notes: Spine title: Anthranilic acid. "CAS no. Cinnamyl anthranilate was tested for carcinogenicity in mice and rats by administration in the diet and in mice by intraperitoneal injection.

In mice, a dose-related increase in the incidence of hepatocellular tumours was found following its oral administration and an increased incidence of lung tumours following its intraperitoneal injection.

Mouse: Cinnamyl anthranilate was tested in a lung adenoma screening assay. In the first series, groups of 15 male and 15 female A/He mice, six to eight weeks of age, were given thrice weekly intraperitoneal injections of cinnamyl anthranilate [purity unspecified] dissolved in tricaprylin, as 24 doses of mg/kg bw (the maximal.

The effects of cinnamyl anthranilate (CA) have been compared in female B6C3F 1 mice and female F rats fed diets containing 0–% CA for periods of 1, 4, and 13 weeks. In the mouse, treatment with CA at all time points produced a marked dose-dependent increase in relative liver weight and hepatic peroxisome proliferation as demonstrated by the induction of peroxisomal (cyanide-insensitive Cited by: 4.

ethylhexyl) adipate and cinnamyl anthranilate) are carcinogenic to the liver in mice and/or rats, and have been proposed to act by a mechanism involving peroxisomal proliferation in hepatocytes in those species.

The role of peroxisome proliferation in evaluating carcinogenicity in humans has been discussed (IARC, b).

When, for. A bioassay of cinnamyl anthranilate (a synthetic flavoring agent) for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were fed the test chemical in diets contain or 30, ppm for weeks and then observed for an additional 2 or 3 weeks. cinnamyl alcohol anthranilate: cinnamyl alcohol, anthranilate: cinnamyl anthranilate (Prohibited for use in food in U.S.

Dot ) Manufactured on special toll basis, min qty applies. Fragrance use only. cinnamyl o-aminobenzoate: cinnamyl ortho-aminobenzoate: 3-phenylpropenyl anthranilate: 3-phenylpropenylaminobenzoate: 3. Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III.

Cinnamyl anthranilate is a synthetic food flavoring and fragrance agent, formerly used at low levels. Although it is not genotoxic, very high doses have been shown to cause liver tumors in mice but not rats. In this report we characterize hepatic changes brought about by cinnamyl anthranilate in rats and by: 6.

CAS Number Synonym(s) Anthranilic acid; Cinnamyl ester; Cinnamyl o-aminobenzoate; NCI-C Occurence(s)/Use(s) Fragrance additive. Banned as food additive (flavoring agent) in. Author(s): Mason Research Institute.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.) Title(s): Bioassay of cinnamyl anthranilate for possible carcinogenicity/ Carcinogenesis Testing Program, National Cancer Institute, National Institutes of Health and.

Independent Ingredients Supplier: We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals,food additives, cosmetic ingredient,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals, as the major.

Bioassay of Trimethylthiourea for Possible Carcinogenicity (CAS No. TR Research Triangle Park, NC:National Toxicology Program, (). Cinnamyl anthranilate causes coinduction of hepatic microsomal and peroxisomal enzymes in mouse but not rat.

Explore information about Air pollutants, contaminants and studies being done. REFERENCES Litton Bionetics Inc. () Mutagenicity evaluation of compound FDAcinnamyl anthranilate (Litton Bionetics Inc., 15 JuneFDA Contract No.

) NCI () Bioassay of cinnamyl anthranilate for possible carcinogenicity, National Cancer Institute, Carcinogenesis Technical Report Series No.NTP No. Prediction of Rodent Nongenotoxic Carcinogenesis: Evaluation of Biochemical source of rodent bioassay data, having as efficiently as possible. ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes.

Substance Information. Cinnamyl anthranilate. Regulatory process names 1 IUPAC names 1 Other identifiers 1. Print infocard. Substance identity Substance identity.Anthranilate is an aminobenzoate that is the conjugate base of anthranilic acid, obtained by deprotonation of the carboxy group.

It has a role as a human metabolite, a mouse metabolite and a Saccharomyces cerevisiae metabolite. It is a conjugate base of an anthranilic acid.Cinnamyl anthranilate.

(PMID) Abstract Citations; Related Articles; Data; BioEntities; External Links; IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans [01 Jul] Type: Journal Article. Abstract. No abstract provided.

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